![]() What makes Aspergillus fumigatus a successful pathogen? Genes and molecules involved in invasive aspergillosis. In this review, we present recent advances in our understanding of Aspergillus fumigatus cell wall polysaccharides, including the emerging role of cell wall polysaccharides in the host-pathogen interaction.Ībad, A., Fernandez-Molina, J.V., Bikandi, J., Ramirez, A., Margareto, J., Sendino, J., Hernando, F.L., Ponton, J., Garaizar, J., and Rementeria, A. As these polysaccharides are absent from the human host, these biosynthetic pathways are attractive targets for antifungal development. ![]() Continuous synthesis and remodeling of the polysaccharides of the cell wall is essential for the survival of the fungus during development, reproduction, colonization and invasion. ![]() The synthesis of cell wall polysaccharides is a complicated process that requires coordinated regulation of many biosynthetic and metabolic pathways. Cell wall polysaccharides are important ligands for the recognition of fungi by the innate immune system and they can mediate potent immunomodulatory effects. Besides protecting the fungus from environmental stresses and maintaining structural integrity of the organism, the cell wall is also the primary site for interaction with host tissues during infection. Over the past several decades, research on the synthesis and organization of the cell wall polysaccharides of Aspergillus fumigatus has expanded our knowledge of this important fungal structure.
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